简介: 彼特·舒斯特(Peter Schuster)教授, 现任奥地利科学院院长

研究方向： 氢键与分子间作用力理论

           关于水溶液中质子转移反作用的动力学

           非线形动力学和复杂可展开系统理论

           分子进化理论

           在DNA(脱氧核糖核酸)复制，选择和优化中对硅和微晶的研究

           RNA(核糖核酸)和蛋白质的结构和性质研究

           关于DNA(脱氧核糖核酸)序列与结构间的影射和neutral networks 在物理，化学,

           神经生物学，遗传调整网络和新陈代谢网络中的非线形微分方程的解析逼近

摘要: Ribonucleic acid molecules, RNAs, came in the focus of current interest in molecular genetics, because they appear to be equally important in regulation of cellular activities of higher organisms as the conventional regulation of gene activities through proteins binding to DNA. RNA molecules in contrast to proteins have a physically meaningful simplified version of structure, called secondary structure, that allows for fairly reliable structure prediction, molecular design, and modeling of evolutionary change. Kinetic folding of RNA molecules and RNA optimization through evolution in populations are modeled as processes taking place in three abstract point spaces: sequence space, shape space, and conformation space. This concept does not only allow for a more general view of the properties of RNA molecules, it turned out also to be particularly important for the design of RNA molecules, which have two or more (meta)stable conformations, so called RNA switches. RNA switches were found in nature as well and were found to be important in the regulation of metabolic processes.